Washington Redskins wide receiver DeSean Jackson left Wednesday's practice with a foot injury and his status for Thursday's preseason opener is in doubt.

Jackson stopped in his tracks and appeared to turn his ankle and foot a defender stepped on Jackson's foot while he running a route in 11-on-11 drills during the third joint practice of the week with the New England Patriots. The teams close out the week with a game a FedEx Field on Thursday.

Coach Jay Gruden said the injury was to Jackson's ankle, which he twisted "just a hair," according to the coach.

"We'll see how he does at rehab or treatment and all that. We'll find out," Gruden said.

Trainers removed Jackson's cleat and socks and iced his foot before helping him off the field. Jackson walked off the field under his own power.

Jackson, a speed receiver in his first summer with the Redskins after signing a four-year deal, is expected to be a lead target for quarterback Robert Griffin III. Wide receiver depth was a concern in 2013, but Pierre Garcon topped 100 receptions and the tema is hopeful tight end Jordan Reed will return from a season shortened by concussions.

Garcon will not play Thursday because of a hamstring strain. He was injured Tuesday in a joint practice with the Patriots.

"DeSean just got hurt today. Pierre just tweaked a hamstring yesterday," Gruden said Wednesday. "Having (joint practices) was a great thing. Actually Pierre hurt his hamstring before the Patriots got here. Hatcher was already hurt obviously before they got here, and DeSean just had a fluke thing today in a walkthrough, which we have walkthroughs all the time -- the guy stepped on his foot, so it was a fluke. Everybody else, it was a great experience, I think, for everybody."