Before his speech, Romney also sat down for a series of interviews with U.S. broadcast and cable networks, including CNN.
In the morning briefing with reporters, Senor explained Romney supports a "two-state solution" for both Israelis and Palestinians in securing a path to peace in the Middle East.
But Senor added Palestinians and other Arab nations would have to understand such a resolution "represents the end of the conflict."
"There should be no right of return," Senor said.
"This is not a platform for new Palestinian refugees down the road to return to Israel. If there is a Palestinian state, that should be the home for Palestinians wanting to return to this region."