(CNN) -

Sen. Kelly Ayotte of New Hampshire, frequently mentioned as a possible running mate for Mitt Romney, floated the idea of debating with Vice President Joe Biden and said she would find the situation "quite enjoyable."

In an interview with the Boston Herald published Tuesday, the junior senator said she "would love" to go head-to-head with Biden on the rising federal debt.

"The vice president does have a way with words," Ayotte joked, according the paper, referring to Biden's reputation for making gaffes on the campaign trail.

Her comments came ahead of the vice president's visit Tuesday to New Hampshire, where he's expected to make a campaign speech on the economy.

"Let's face it, he has got a very different vision of this country than I do," she said. "I think Joe Biden's vision is one of big government. We've seen that that doesn't work."

Ayotte has frequently stumped for Romney this cycle, making several appearances with the candidate prior to her state's January primary. More recently, she introduced Romney at a campaign event in New Hampshire at the end of April.

With strong conservative credentials and a key position in an important state, some political observers speculate she could be on the candidate's list of possible running mates.

Her biggest disadvantage, former New Hampshire Gov. John Sununu argued, is geography. Because she and Romney are from both from the northeast, she may not offer as much appeal to bigger swing states, the Romney surrogate told reporters last month.

While many potential VP contenders often attempt to push back on running mate talk, Ayotte's comments are the latest in a string of remarks signaling she may be eying the gig.

Earlier this month, she made headlines when she said in a television interview that she had "better experience" than Obama did during his 2008 run for president.

And in the Herald interview this week, she admitted she liked one of the paper's headlines earlier this year that named her as a potential running mate choice. She said her "family purchased multiple copies" of the paper.