The Home Depot in La Quinta was robbed just before 11 am Monday.
The Sheriff's Department is investigating the robbery on Jefferson and Highway 111 in La Quinta.
The suspect fled out of the store, and injured a security guard who suffered a cut to his arm.
The suspect is described as Black Male adult in late 40's, 5'10, 200 lbs, last seen wearing an orange shirt and blue jeans.
Deputies are currently looking in the area for the suspect.