"The last thing that's going to enter your mind is news from the cycling world," McClain said Wednesday.
According to Livestrong, Armstrong has helped raise nearly $500 million, including $6.5 million of his own, for cancer research, treatment and support in his role as Livestrong founder and has helped "dispel the stigma and misconceptions about the disease."
Livestrong will need to find a new way to present itself to the world without Armstrong as its face, said Eric Martin, a partner with Boost Partners, a Richmond, Virginia, strategic consulting firm.
How? Focus on "real-world heroes who have faced down cancer while loving a sport more than the spotlight," Martin said.
"At this point, what they need to do is re-establish the authenticity of their cause and the way to do that, in my opinion, is to reconnect with what people really admire in their heroes," Martin said.
Howard Bragman, an expert in crisis communications and vice chairman of Reputation.com, an online reputation management company in Los Angeles, said the future of Livestrong is uncertain.
"I personally hope that Livestrong is stronger than Lance Armstrong because they have done -- and continue to do -- amazing work for people with cancer," he told CNN in a telephone interview.
But he said he had little doubt that the impact on Armstrong would be devasating. "It doesn't get any worse than this, OK?" he told CNN in a telephone interview. "Imagine losing the prestige of all your Tour de France titles, millions in endorsements, stepping down from the organization he loves and founded, that's been his public mission -- and, possibly the worst thing of all, which is public humiliation."