George Clooney through the years

POSTED: 08:32 AM PDT Jun 15, 2011    UPDATED: 11:00 PM PDT May 05, 2013 

With George Clooney celebrating his 52nd birthday May 6, take a look back at his career so far, from "Facts of Life" and "ER" to his most recent work.

George Clooney, O Brother Where Art Thou
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Touchstone Pictures

"O Brother, Where Art Thou?," the Coen Brothers' 2000 take on Homer's "Odyssey," gave Clooney the chance to have the best-reviewed performance of his career to that point.

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