Hillary Clinton (Born Oct. 26, 1947)
A former first lady and a U.S. senator, Hillary Clinton set out on a historical journey last year to become the first woman U.S. president. She fell short in her bid to capture the Democratic nomination, but she was appointed a new role by President Barack Obama -- Secretary of State.
Katie Couric (Born Jan. 7, 1957)
After serving as co-host of NBC's "Today," Katie Couric made a jump to "CBS Evening News" in 2006. The move -- which resulted in times of ups and downs for the journalist -- allowed Couric to become the first solo female anchor of a national evening news program on one of the three major U.S. networks -- ABC, CBS and NBC.
Caroline Kennedy (Born Nov. 27, 1957)
The daughter, and only surviving child, of former president John F. Kennedy, Carolina Kennedy has stepped forward into her own political career as of late. A spokesman for her family and also an author, in 2008, Kennedy -- along with her uncle Ted Kennedy -- endorsed Barack Obama for president. She also later served as co-chair of his Vice Presidential Search Committee, and spoke at the 2008 Democratic National Convention. Kennedy has recently been mentioned as a possible successor to fill Clinton's New York Senate seat.
Michelle Obama (Born Jan. 17, 1964)
A married lawyer and a mother a two daughters, Michelle Obama now has a new title -- first lady of the U.S. After helping her husband campaign around the U.S. en route to winning the 2008 presidential election, Obama is now working to make a home in the White House, help her daughters adjust to new schools and a new city, and serving her duties as first lady.
Condoleezza Rice (Born Nov. 14, 1954)
After serving as President George W. Bush's National Security Adviser during his first term as president, Condoleezza Rice was named the U.S. Secretary of State during Bush's second term. Her appointment made her the first black woman and the second woman ever to hold the position. Rice ended her tenure as Secretary of State in January, when Bush's presidency came to an end. She will be succeeded by another woman -- Clinton.
Sharon Stone, (Born March 10, 1958)
Considered one of the sexiest actresses in Hollywood, Stone continues to turn heads even in her 50s. Stone, who was nominated for an Academy Award in 1996 for her role in Casino, was named one of the "Top 50 Hottest Babes Ever" in 2006 by the Australian men's magazine Zoo Weekly.
Meryl Streep (Born June 22, 1949)
Award-winning actress Meryl Streep, who won Oscars for her performances in "Kramer Vs. Kramer" and "Sophie's Choice," hasn't slowed down. She received an Academy Award nomination for best actress in 2007 for her role in "The Devil Wears Prada." She filled theaters with her musical performance in "Mama Mia" and then showed her dramatic talents in "Doubt" in 2008. Both performances earned Streep Golden Globe nominations.
Emma Thompson (Born April 15, 1959)
Two-time Oscar winner Emma Thompson has been honored for her writing and acting abilities, winning Academy Awards in 1996 for best writing/best screenplay for "Sense and Sensibility," and best actress in 1993 for her role in Howards End. As she nears 50, Thompson's talents continue to impress critics, as she was nominated this year for a Golden Globe for best actress for her role in "Last Chance Harvey."
Meredith Vieira (Born Dec. 30, 1953)
Meredith Vieira is a daily fixture in households across the U.S. as co-host of NBC's "Today." Vieira left ABC's "The View" in 2006 to succeed Couric on the morning news show. Vieira also hosts the game show "Who Wants To Be A Millionaire" in syndication.
Oprah Winfrey (Born Jan. 29, 1954)
The host of one of the highest-rated talk shows, Oprah Winfrey has used her status to launch a magazine, a book club and sponsor philanthropy projects. Her success has made her one of the most influential women in the world.